Altrenogest during early pregnancy modulates uterine glandular epithelium and endometrial growth factor expression at the time implantation in pigs

This study evaluated the effects of supplying altrenogest from day 6-12 pregnancy on endometrial glandular epithelium, corpora lutea (CL) morphology, and CL gene expression. A total 12 crossbred females (Landrace × Large White) were used. The assigned to 4 treatments according a random design with 2 factorial arrangement, two categories (sow or gilt) (non-treated treated altrenogest). On 6 pregnancy, animals allocated one following groups: non-treated (NT, n = 6; 3 sows gilts), (T, gilts) daily 20 mg altrenogest, pregnancy. All euthanized 13 CLs individually weighed, their volume determined. density (GD), mean area (MGA), vascular (VD) determined by histomorphometric immunohistochemical analyses. Endometrium samples collected analyzed qRT-PCR evaluate abundance transcripts for VEGF IGF-I. Females in T group had higher MGA (P < 0.05) compared NT group. There was no effect treatment GD VD both experimental groups. Sows augmented expression IGF-I 0.05). Progestagen detrimental morphology. In conclusion, improves uterine environment during peri-implantation period pigs without compromising development.